Sunday, September 28, 2008

How Does Ellagic Acid Exert An Anti-Cancer Effect On Pancreatic Cancer Cells?

"Ellagic acid was previousely shown to have anticarcinogenic, antioxidant and antifibrosis properties. The anticarcinogenic effect of ellagic acid was shown in several types of cancers including skin, esophageal, and colon cancers. However the mechanisms mediating anti-cancer effect of ellagic acid, in general, remain unknown.

A research article published on 21 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Edderkaoui from West Los Angeles VA Healthcare Center showed that Ellagic acid increases programmed cell death and decreases proliferation of pancreatic cancer cells. They showed that the mechanism through which ellagic acid causes cell death is through decreasing the activity of the pro-survival transcription factor NF-kB. The compound does not affect mitochondria. The results presented in this article show for the first time how this polyphenol regulates cancer cell proliferation and resistance to death and may help surpass the resistance of these cells to radio and chemotherapies. "

2 comments:

THARANI PRAKASH said...

ellagic acid is a fantastic oppresive agent and i am a research student , read about this article , it was a great use to me thank you anyway i wanted to share relevatn information with you , i am taking proleva tablets for my food supplements , it was a good advice from my doctor and also is a source of ellagic acid ,just wanted to inform in this relevant post , keep up the good blogs coming in , bye here is the link -www.tryproleva.com ,shipping was very fast and the service was good , ok people bye and hope my comment helps

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